Alzheimer's β-Amyloid Peptide 1-42 Induces a Phagocytic Response in Murine Microglia
نویسندگان
چکیده
منابع مشابه
Shuttling protein nucleolin is a microglia receptor for amyloid beta peptide 1-42.
Amyloid-beta peptide 1-42 (Aβ42) plays a key role in the neurotoxicity found in Alzheimer's disease. Mononuclear phagocytes in the brain (microglia), can potentially clear Aβ via phagocytosis. Recently, the shuttling-protein nucleolin has been shown to possess scavenger receptor-activity. Here, we investigated whether this receptor interacts specifically with Aβ type 1-42 and mediates its phago...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2002
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.1998.71052123.x